Going beyond simple sample size calculations: A practitioner's guide

Arbeitspapier

Basic methods to compute the required sample size are well understood and supported by widely available software. However, the sophistication of the sample size methods commonly used has not kept pace with the complexity of the experimental designs most often employed in practice. In this paper, we compile available methods for sample size calculations for continuous and binary outcomes with and without covariates, for both clustered and non-clustered RCTs. Formulae for panel data and for unbalanced designs (where there are different numbers of treatment and control observations) are also provided. The paper includes three extensions: (1) methods to optimize the sample when costs constraints are binding; (2) simulation methods to compute the power of a complex design; and (3) methods to consider in the sample size calculation adjustments for multiple testing. The paper is provided together with spreadsheets and STATA code to implement the methods discussed.

Object Details

• Language: Englisch

References and Relationships

• Bibliographic citation: Series: IFS Working Papers ; No. W15/17

Classification and Topics

• Classification: Wirtschaft
• Subject: Power analysis ; Sample size calculations ; Randomised Control Trials ; Cluster Randomised Control Trial ; Covariates ; Cost Minimisation ; Multiple outcomes ; Simulation

Contributors, Location and Time

• Event: Geistige Schöpfung
• (who): McConnell, Brendon ; Vera-Hernández, Marcos
• Event: Veröffentlichung
• (who): Institute for Fiscal Studies (IFS)
• (where): London
• (when): 2015

Further information

• DOI: doi:10.1920/wp.ifs.2015.1517
• Handle: http://hdl.handle.net/10419/119557
• Last update: 20.09.2024, 8:20 AM CEST